Proprioceptive feedback

Proprioceptive feedback has been studied in the context of Autism to understand its potential role in the motor impairments and sensory processing differences and altered personal space.

Proprioceptive feedback refers to the sensory information that our body receives regarding the position, movement, and orientation of our body parts. It is a crucial component of our overall perception and awareness of our body in space. This feedback allows us to have a sense of where our body is located, how it is moving, and how our limbs are positioned without having to visually observe them.

Proprioception is mediated by specialized receptors known as proprioceptors, which are found in muscles, tendons, ligaments, and joints. These proprioceptors detect changes in muscle length, muscle tension, joint angles, and joint pressure. They provide constant input to the central nervous system, particularly the brain and spinal cord, enabling us to have a continuous sense of our body's position and movement.

Examples of proprioceptors

• the muscle spindle located within skeletal muscles, responds to changes in muscle length. When a muscle is stretched or contracted, the muscle spindle sends signals to the CNS, providing information about the degree and speed of muscle stretch. This information helps the brain monitor and control muscle activity, contributing to coordinated movement.
• Golgi tendon organ, located at the junction between muscles and tendons, responds to changes in muscle tension or force exerted on the tendon. When muscle tension increases, the Golgi tendon organ detects this change and sends signals to the central nervous system, allowing for adjustments in muscle force and preventing excessive muscle contraction.
• Joint receptors  found in the capsules and ligaments surrounding joints,  detect changes in joint position and movement. There are different types of joint receptors, including Ruffini corpuscles, Pacinian corpuscles, and free nerve endings, each specialized for different aspects of joint movement. These receptors provide information about joint angles, joint velocity, and joint pressure, allowing for precise control of limb movements.

Proprioceptive feedback is integrated with other sensory information, such as visual and vestibular input, to provide a comprehensive perception of body position and movement. The brain combines these different sensory inputs to create a coherent representation of the body in space, known as body schema.

Research has shown that proprioception plays a vital role in motor control, coordination, and balance. Impairments in proprioceptive feedback can lead to difficulties in performing precise movements, maintaining balance, and coordinating multiple body parts. For example, individuals with certain neurological conditions or injuries affecting proprioceptive pathways may experience problems with coordination and a reduced awareness of their body's position, potentially leading to increased risk of falls or accidents.



Citations around Proprioceptive Feedback
Proske U, Gandevia SC. The Proprioceptive Senses: Their Roles in Signaling Body Shape, Body Position and Movement, and Muscle Force. Physiol Rev. 2012;92(4):1651-1697. doi:10.1152/physrev.00048.2011
Gandevia SC, McCloskey DI. Joint Sense, Muscle Sense, and Their Combination as Position Sense, Measured at the Elbow. J Physiol. 1976;260(2):387-407. doi:10.1113/jphysiol.1976.sp011306
Roll JP, Vedel JP. Kinaesthetic Role of Muscle Afferents in Man, Studied by Tendon Vibration and Microneurography. Exp Brain Res. 1982;47(2):177-190. doi:10.1007/BF00239352
Gandevia SC. Kinesthesia: Roles for afferent signals and motor commands. In: Comprehensive Physiology. John Wiley & Sons, Inc.; 2011. doi:10.1002/cphy.c100058

Specific to Autism
Marco, E. J., Hinkley, L. B., Hill, S. S., & Nagarajan, S. S. (2011). Sensory processing in autism: a review of neurophysiologic findings. Pediatric Research, 69(5 Pt 2), 48R-54R. doi: 10.1203/PDR.0b013e3182130c54
Torres, E. B., & Donnellan, A. M. (2013). Autism: the micro-movement perspective. Frontiers in Integrative Neuroscience, 7, 32. doi: 10.3389/fnint.2013.00032
Haswell, C. C., Izawa, J., Dowell, L. R., Mostofsky, S. H., & Shadmehr, R. (2009). Representation of internal models of action in the autistic brain. Nature Neuroscience, 12(8), 970-972. doi: 10.1038/nn.2356
Glazebrook, C. M., Gonzalez, D. A., Hansen, S., Elliott, D., & Lyons, J. (2009). Impaired visuo-motor processing contributes to altered personal space in autism. Neuropsychologia, 47(13), 2811-2817. doi: 10.1016/j.neuropsychologia.2009.06.021
Cascio, C. J., Foss-Feig, J. H., Heacock, J., & Newsom, C. R. (2012). Tactile perception in adults with autism: a multidimensional psychophysical study. Journal of Autism and Developmental Disorders, 42(11), 2270-2282. doi: 10.1007/s10803-012-1486-2
Hilton, C. L., Zhang, Y., Whilte, M. R., Klohr, C. L., & Constantino, J. N. (2012). Motor impairment in sibling pairs concordant and discordant for autism spectrum disorders. Autism, 16(4), 430-441. doi: 10.1177/1362361311435155
Glazebrook, C. M., & Elliott, D. (2010). Vision-action coupling for perceptual control of posture in children with and without autism spectrum disorders. Developmental Science, 13(5), 742-753. doi: 10.1111/j.1467-7687.2009.00941.x

Comparing the ABC and CATI Autism Measures

Autism Assessments & Measures 

The Aberrant Behavior Checklist (ABC) and the Comprehensive Autistic Trait Inventory (CATI) are both tools used to assess behaviors and traits associated with autism, but they differ in their specific focus, structure, and use cases. Here’s a comparison to highlight the differences between the two:

[Posts on other Assessment Tools and Diagnostic Measures] 

Aberrant Behavior Checklist (ABC)

Purpose: Designed to assess the presence and severity of problem behaviors in individuals with developmental disabilities, including autism.

Structure: Consists of 58 items divided into five subscales:

• 1. Irritability
  2. Lethargy/Social Withdrawal
  3. Stereotypic Behavior
  4. Hyperactivity/Noncompliance
  5. Inappropriate Speech

Administration:

• Completed by caregivers, teachers, or clinicians who are familiar with the individual's behavior.
• Uses a Likert scale (0-3) to rate the severity of each behavior.

Focus:

• Measures the severity and frequency of specific problem behaviors.
• Used to track changes over time and assess treatment effectiveness.

Advantages:

• Provides detailed information about specific behavioral issues.
• Useful for treatment planning and monitoring progress.

Limitations:

• Subjective responses from raters.
• Does not provide a comprehensive assessment of autism traits.

Comprehensive Autistic Trait Inventory (CATI)

Purpose: Designed to provide a detailed assessment of the range of autistic traits across various domains, specifically for research and clinical purposes.

Structure: The exact structure may vary, but typically includes multiple domains that cover:

• 1. Social Interaction
  2. Communication
  3. Restricted and Repetitive Behaviors
  4. Sensory Sensitivities
  5. Cognitive Traits
  6. Emotional Regulation

Administration:

• Can be completed by individuals with autism (self-report), parents, or clinicians, depending on the version.
• Uses a comprehensive rating scale to assess the frequency and intensity of various autistic traits.

Focus:

• Provides a broad and detailed overview of autistic traits across multiple domains.
• Aims to capture the full spectrum of autism-related characteristics for both diagnostic and research purposes.

Advantages:

• Offers a comprehensive assessment of a wide range of autistic traits.
• Useful for identifying strengths and areas of need in individuals with autism.

Limitations:

• Can be more time-consuming due to its comprehensive nature.
• May require detailed knowledge of the individual’s behaviors and traits.

Key Differences

1. Focus:

   • ABC: Focuses on assessing and quantifying specific problem behaviors.
   • CATI: Focuses on providing a comprehensive assessment of a wide range of autistic traits across multiple domains.

2. Structure:

   • ABC: 58 items across five subscales related to problem behaviors.
   • CATI: Multiple domains covering social interaction, communication, repetitive behaviors, sensory sensitivities, cognitive traits, and emotional regulation.

3. Administration:

   • ABC: Typically completed by caregivers or teachers.
   • CATI: Can be completed by individuals with autism, parents, or clinicians, depending on the version.

4. Purpose:

   • ABC: Used for identifying problem behaviors, planning treatment, and monitoring changes over time.
   • CATI: Used for a detailed assessment of autistic traits for both diagnostic and research purposes.

5. Rating Scale:

   • ABC: Uses a Likert scale (0-3) to rate the severity of each behavior.
   • CATI: Uses a comprehensive rating scale to assess the frequency and intensity of various autistic traits.

In Essence, while the ABC is focused on problem behaviors and is useful for clinical treatment planning, the CATI provides a broad and detailed assessment of the full range of autistic traits, making it valuable for both clinical and research applications.

For Related Posts on other Measures in Autism

Posts on Aberrant Behavior Checklist (ABC)

Posts on Comprehensive Autistic Trait Inventory (CATI) 

Serenity is the healing that comes with being kind to ourselves.

To create is discover a world within yourself

 

Towards a more Humane Society. Contemplation one line a day. #MentalHealth.

Ableism

Ableism refers to systemic discrimination and prejudice against individuals with disabilities, including autism, often manifesting through societal norms, policies, and practices that marginalize and devalue their experiences and abilities.

PlainSpeak: Ableism is when people with disabilities, like autism, are treated unfairly or seen as less capable, because of biased attitudes and rules in society.

Most Posts on [Ableism]

Mental Time Travel

The concept of mental time travel (MTT) refers to our ability to mentally project themselves backward in time to relive or remember past events, as well as forward in time to imagine or anticipate future events. It is a cognitive process that allows us to mentally simulate and navigate through temporal experiences beyond the present moment.

The MTT Task

The MTT task is a neuroscience measure designed to assess an individual's capacity for mental time travel. Participants are presented with event cues, such as "graduation" or "vacation," and asked to recall a specific past event or imagine a specific future event related to each cue. This task distinguishes between personal events, which are specific episodic memories from one's own life, and general events, which are more abstract and can be shared by multiple people, such as public holidays or significant historical moments. In this task, the individual's present moment serves as a reference point from which they situate and retrieve personal versus general events. 

The MTT task has been used in research to investigate individual differences in the capacity for mental time travel and how it relates to various cognitive processes, such as autobiographical memory, imagination, planning, and self-projection. It has also been employed to examine the effects of aging, neurodegenerative diseases, and psychiatric disorders on mental time travel abilities.

Cognitive Processes and Neural Mechanisms

MTT involves several cognitive processes, including memory recall, imagination, and prospective thinking. Neuroimaging studies reveal that MTT engages a network of brain regions which include.

• Prefrontal Cortex (PFC). Involved in cognitive control and executive functions, critical for retrieving and manipulating temporal information.
• Hippocampus and Medial Temporal Lobe (MTL). Essential for the formation and retrieval of episodic memories, these areas help us construct detailed, context-rich memories and future scenarios.

MTT and Autism: A Research Frontier

Studies have shown that individuals with autism may exhibit differences in episodic memory and future-oriented thinking, which are key components of MTT.

For example, research suggests that some autistics may have difficulty recalling specific personal events and constructing detailed future scenarios, possibly due to challenges in episodic memory retrieval and imagination . However, the variability within the autism spectrum means that these experiences can differ widely among individuals.

Investigating MTT in autism could provide valuable insights into how autistics perceive and engage with time-related cognitive processes. Future studies could explore,

• Episodic Memory Retrieval: Understanding how autistics recall personal versus general events.
• Imagination and Future Planning: Examining the ability to construct detailed and plausible future scenarios.
• Neural Correlates: Using neuroimaging to explore the brain regions involved in MTT and how they may differ in  autism.

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Versions of this post: [PlainSpeak For the Lay Reader], [For the Academic/Science Reader], [A Simple Definition]

Related Posts: [Autism Theories], [Sensorimotor], [Neuroscience of Autism]

References
Lind, S. E., & Bowler, D. M. (2010). Episodic memory and episodic future thinking in adults with autism. Journal of Abnormal Psychology, 119(4), 896–905. https://doi.org/10.1037/a0020631

Creativity is the bridge between art and science

Towards a more Humane Society. Contemplation one line a day. #MentalHealth.

 

If you know everything, you are not learning

 Something Professor Carissa Cascio shared with the lab today. So appropriate. 

Also accompanied by a message encouraging us to "be confident in asking questions and not worried about what they don't know. If you already know everything, you're not learning!"

Thank you for this assurance cuz my rather atypical educational path leaves me wondering (more often than not) if there are things I have missed out (through the typical NT education path,  NT social experiences/interactions/networking) which is now maybe impacting my knowledge and work. 

Media Mention

 

The need for global solutions. Disability is not an american phenomena.

Creativity is the language of the heart

Towards a more Humane Society. Contemplation one line a day. #MentalHealth.

 

Imagination is the foundation of creativity

Towards a more Humane Society. Contemplating, one line a day. #MentalHealth.

 

Creativity is the art of bringing things to life

 Contemplation one line a day. #MentalHealth.

 

Severe Weather Nashville - Spring Edition

Nashville sure has a lot of severe weather alerts.
This is a running tab for Spring Mar 30- Jun 20

(see here for winter)

Neuro-verse

Neuro-verse

My mind sings verses that caress the senses, transforming my world into a synesthetic tapestry of words.
My brain, a maestro of emotions, conducts a raaga of imagery, metaphor, and laya, serenading the sensory symphony with poetic canvas.

Neurotransmitters thread words with grace, enchanting the sensory realm with refrains that waltz through the mind like melodic raagas.
Neurons engage in taal, harmonizing synapses with the hues of perception, painting poetry that captivates the optic cortex and cochlear nerve.

Dynamic neuroplasticity conducts a jugalbandi of words that sculpts multidimensional space, leaving the synapses swaying to the rhythm of words.
Neural artistry entwines poetry and swara, every ERP, illuminating kaleidoscopic realms.

from Indian Classical Music: Raaga (musical scale), Laya (rhythm), Taal (beat), Swara (musical note), 

Jugalbandi (collaborative improvisation).

ERP: Event Related Potential -   neuroscience measure (using EEG) to assess the electrical activity of the brain in response to specific events or stimuli.

Kindness is not a weakness its a superpower

Creativity is the ultimate form of self expression

 

Towards a more Humane Society. Contemplation one line a day. #MentalHealth.

CATI - Comprehensive Autism Trait Inventory

 

• The Comprehensive Autism Trait Inventory (CATI) is a new measure of autistic traits that reflects our current understanding of autism and includes subscales for social camouflage and sensory sensitivity.
• The 42 items are divided into 6 subscales of "Social Interactions,” “Communication,” "Social Camouflage,” "Cognitive Rigidity,” "Repetitive Behaviours,” and "Sensory Sensitivity” (each with 7 items).
• It is free to use. 

[Related Posts on CATI]

Psychometrics

• (English et al., 2021) is a first validation paper that has included 3 separate studies.
• The CATI showed convergent validity and superior internal reliability compared to existing measures like the AQ and BAPQ
• The CATI provides a comprehensive assessment of trait dimensions associated with autism, potentially eliminating the need for multiple measures, and has the potential to improve research on autistic traits in the general population.

The English et al (2021) article discusses the need for a new measure of autistic traits that reflects our current understanding of autism. The article describes the development and validation of the CATI, comparing it to existing measures such as the Autism-Spectrum Quotient (AQ) and the Broad Autism Phenotype Questionnaire (BAPQ). The CATI demonstrates convergent validity, superior internal reliability, and greater predictive ability for classifying autism compared to the other measures. It is also the first measure to have dedicated subscales for social camouflage and sensory sensitivity. The authors conclude that the CATI provides a reliable and comprehensive assessment of autistic traits, addressing the limitations of existing measures

• (Meng & Xuan, 2023) - A Mandarin Chinese translation of CATI that was recently validated (although only 35 of the 42 items made it into that version, likely due to issues with the model fit of the translated measure). The Chinese group also derived a 24-item short form of the Chinese CATI which appears to have good psychometrics as well. 

References
English, M.C.W., Gignac, G.E., Visser, T.A.W. et al. The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population. Molecular Autism 12, 37 (2021). https://doi.org/10.1186/s13229-021-00445-7

Meng F, Xuan B. Psychometric Properties of the Chinese Version of the Comprehensive Autistic Trait Inventory. Psychol Res Behav Manag. 2023 Jun 15;16:2213-2223. doi: 10.2147/PRBM.S411599. PMID: 37342828; PMCID: PMC10278863.

Joy is the music that fills our soul and lifts us up

 

Contemplation, one line a Day. 

 

Creativity is the key to unlocking the doors of the unknown

Towards a more Humane Society. Contemplation one line a day. #MentalHealth.

 

ASSERT ECHO @Vandy

I have been a participant in the Assert (All Stakeholders Engage in Research Together) project this semester, run by Prof Beth Malow's Sleep Lab.  https://www.vumc.org/sleep-in-autism/assert-resources

Its been a good experience, listening to everyone's perspective and being able to contribute, though I could not make last few sessions as it clashed with the new meetings at my new lab rotation.

The disability rights mantra has long centered around Nothing about us without us. And I am glad that to see this idea trickling down with respect to research which will (hopefully) lead us to solutions. And this effort is at happening at many places now - at universities and research centers. 

If you are an autistic, please do consider getting involved by emailing assert@vumc.org. It is important that our voices are heard.