How Autism Changes Perception

 Seeing the World in More Detail: How Autism Changes Perception

Imagine walking into a busy street market. Most people see a blur of color and activity, a rush of sounds blending together—a vibrant but overwhelming scene. But for some autistics, this moment might feel different. They could notice the intricate patterns on the fabrics hanging in a shop, the slight variations in pitch from different voices, or the distinct texture of the pavement underfoot. These details pop out in a way that others might miss.

This heightened ability to perceive the world in more detail is a central idea behind the Enhanced Perceptual Functioning (EPF) model of autism. Proposed by Laurent Mottron and his team, the EPF model offers a refreshing way of understanding the sensory differences experienced by autistics —not as deficits, but as strengths.

What is the Enhanced Perceptual Functioning Model?

In simple terms, the EPF model suggests that many autistics have superior abilities when it comes to perceiving certain types of sensory information. This might mean they can pick up on subtle visual details, hear sounds that others tune out, or feel textures more intensely.

Let’s break down the key ideas:

• Enhanced Sensory Abilities: Autistics might outperform NTs  in tasks like detecting fine details, distinguishing sounds, or noticing tiny changes in the environment. For example, while most of us might not notice a slight shift in a pattern, an autistic may immediately pick up on it.

• Details Over Big Picture: One core idea of the EPF model is that perception tends to take precedence over higher-level cognitive processes like interpretation. While many people naturally try to see the “big picture” of what’s happening around them, autistics may focus more on specific details. This is why, in certain tasks, they excel at noticing things that others would miss.

• Perception Runs Independently: The EPF model also suggests that autistic individuals’ sensory processing may work more independently from top-down cognitive influences like attention or expectations. This autonomy can allow for a clearer, less biased perception of the world, but it can also mean that irrelevant stimuli are harder to filter out, sometimes leading to sensory overload.

• Strengths, Not Impairments: Where traditional models might view sensory sensitivities as impairments, the EPF model reinterprets them as the byproducts of enhanced sensory functioning. An autistic person might experience sensory overload because they are perceiving far more detail than the average person, not because their brain is malfunctioning.

Seeing Sensory Differences Through a New Lens

What does this mean in practice? Imagine that someone with autism is in a noisy restaurant. Instead of just hearing the hum of conversation, they may notice every individual voice, the clinking of silverware, the hum of the air conditioner—every layer of sound. In this scenario, sensory overload can occur because they’re processing more sensory input, not less. Their brain is tuned into the fine details of the environment.

But these heightened perceptual abilities can also be a tremendous strength. Consider autistic artists who create incredibly detailed, realistic drawings, or musicians who can identify subtle differences in pitch. This kind of attention to detail has led to extraordinary achievements in various fields, from scientific research to creative arts.

Beyond the Stereotypes: Autism’s Hidden Potential

The EPF model encourages us to move beyond the deficit-based view of autism, which focuses solely on challenges. Instead, it invites us to think about the hidden potential that comes with enhanced sensory abilities. For instance, many autistics have made major contributions to fields that require precise attention to sensory detail, like visual arts, music composition, and even coding.

By recognizing and embracing these strengths, we can create environments that allow autistic people to thrive. Schools, workplaces, and social settings can be designed to harness these abilities, turning what might traditionally be viewed as a challenge into a powerful tool.

A Shift in Thinking

The Enhanced Perceptual Functioning model of autism offers a new way to understand sensory experiences in autism—not as impairments, but as areas of enhanced ability. This shift in thinking has profound implications for how we support, educate, and interact with autistic individuals. It encourages us to focus on the strengths that often come with heightened perception and to consider how those strengths can be celebrated and integrated into society.

Next time you’re in a bustling environment, pause and think: what if you could notice every small detail, every nuance of sound and texture? For some, this is not just a possibility—it’s their reality, and it comes with both challenges and strengths.

Weak Central Coherence Theory

 The Weak Central Coherence Theory (WCC) of autism, proposed by Uta Frith in the late 1980s and further developed by others, is a cognitive theory that attempts to explain some of the characteristic features of autism. The theory posits that autistics tend to process information in a detail-focused manner, often at the expense of global or contextual processing. 

Key Components of WCC Theory:

1. Detail-Focused Processing:
• Autistics are more likely to focus on the individual components of a stimulus rather than integrating these components into a coherent whole. This is sometimes referred to as "local processing" or "piecemeal processing.” Eg:  notice the specific features of a face, like the shape of the nose or the color of the eyes, rather than perceiving the face as a unified whole.
2. Reduced Global Processing:
• The theory suggests that there is a relative weakness in processing global or contextual information. This means that autistics might have challenges in seeing the "big picture" or understand the context in which details fit.
• For example, they might have difficulty understanding the main idea of a story or the overall mood of a social situation because they are focused on specific details.

Implications of Weak Central Coherence:

1. Cognitive Strengths:
• The detailed-oriented processing style can lead to strengths in tasks that require attention to detail, such as certain types of puzzles, mathematical problems, or tasks involving pattern recognition.
• Autistics may excel in fields that value precision and attention to minute details.
2. Social and Communication Challenges:
• Difficulty in integrating social cues and contextual information can contribute to challenges in social communication and understanding. For instance, recognizing social subtleties or understanding non-literal language (such as idioms or sarcasm) can be difficult.
• Problems with central coherence might also affect understanding narratives, jokes, and metaphors that rely on context.
3. Perceptual and Sensory Processing:
• Some research suggests that weak central coherence is related to atypical sensory processing seen in autism, where individuals might have heightened or diminished sensitivity to sensory input.
• This can manifest as either an intense focus on specific sensory details or difficulty in filtering out irrelevant sensory information.

Weak Central Coherence Theory of Autism

Caveat: There is no single theory that can fully explain autism. 

The Weak Central Coherence Theory posits that autistics exhibit a cognitive processing style characterized by a propensity for local over global information processing. This theory suggests that autistics have a heightened focus on fine details at the expense of integrating these details into a coherent whole. 

The Weak Central Coherence Theory provides a framework for understanding the distinct cognitive processing style in autism, characterized by a bias toward local over global processing. Neurobiological evidence supports this theory, showing enhanced local processing capabilities and impaired global integration due to altered neural connectivity. This theory helps explain the strengths and challenges faced by individuals with autism in various cognitive and social domains.

Key Concepts

1. Detail-Focused Processing:

   • Cognitive Tendency: Autistics demonstrate superior performance on tasks requiring attention to fine details, suggesting an enhanced local processing bias.
   • Neurobiological Basis: Neuroimaging studies indicate increased activation in primary and secondary sensory cortices, particularly the visual cortex, which may underlie this enhanced local processing.

2. Reduced Global Integration:

   • Cognitive Deficit: There is a relative impairment in synthesizing details into a unified, overarching context, which affects higher-order cognitive tasks.
   • Neurobiological Basis: This deficit is associated with reduced long-range connectivity and synchronization between frontal and posterior brain regions, impairing the integration of information across neural networks.

3. Neuroanatomical Correlates:

   • Prefrontal Cortex: Involvement in executive functions and global processing is diminished, contributing to difficulties in integrating complex information.
   • Posterior Regions: Including the occipital and parietal lobes, these regions exhibit enhanced local processing but reduced integration with other cortical areas.

Examples and Implications

1. Perceptual Tasks:

   • Enhanced Performance: Autistic individuals often excel at visual search tasks, identifying small differences in stimuli more quickly and accurately than neurotypical individuals.
   • Impaired Performance: They may struggle with tasks that require understanding the overall context, such as interpreting ambiguous figures or scenes.

2. Cognitive Tasks:

   • Strengths: Detail-oriented tasks like pattern recognition or mechanical assembly are areas of strength.
   • Weaknesses: Tasks requiring abstract thinking, such as comprehending proverbs or making inferences, present challenges due to impaired global processing.

3. Social Interaction:

   • Implications: Social difficulties can arise from an inability to integrate social cues into a cohesive understanding of social interactions. This can lead to literal interpretations of language and difficulties with nonverbal communication.

Neuroimaging Evidence

1. Functional MRI (fMRI):
   • Findings: fMRI studies show atypical activation patterns in the frontal and parietal regions during tasks requiring global processing.
2. Diffusion Tensor Imaging (DTI):
   • Findings: DTI studies indicate atypical white matter integrity, suggesting disrupted long-range connectivity essential for global information integration.
3. EEG/MEG:
• Findings: EEG and MEG studies reveal reduced coherence and synchronization across distant brain regions, supporting the notion of impaired global processing.

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The Role of Parvalbumin Neurons in Autism

A PlainSpeak version for the Lay Reader

The Role of Parvalbumin Neurons in Autism

Background

Scientists believe that a special type of brain cell called Parvalbumin (PV) interneurons (INs) may play a key role in autism. Even though autism can be caused by many different genetic and environmental factors, people with autism often show similar behaviors. This suggests that there might be a common issue in the brain across different individuals with autism (1).

Understanding the role of PV+ interneurons in autism helps us see why many symptoms of autism occur, like sensory sensitivity and seizures. 

The Balance of Brain Signals

Our brains need a balance between "go" signals (excitation) and "stop" signals (inhibition) to work properly. In autism, it was first thought that there is too much excitation and not enough inhibition, leading to an imbalance. This imbalance could explain why some people with autism have seizures (4,5). However, this idea is too simple because many types of brain cells are involved in maintaining this balance.

What We Know About PV+ Cells in Autism

Researchers have found that PV+ cells in the brains of autistics are often not working as they should:

• Fewer PV+ cells: There are fewer of these cells in the brain, and they produce less of a protein called parvalbumin.
• Changes in brain waves: These cells help control brain waves called gamma oscillations. In autism, the power of these gamma waves is higher than normal.
• Reduced activity: PV+ cells show less activity in response to visual signals.

PV+ cells are the most common type of inhibitory ("stop/slow down") neuron in the brain, but other types of neurons may also be involved in autism.

Brain Excitability and Sensory Sensitivity

When PV+ cells don't function properly, the brain becomes overly excitable and synchronized, making seizures more likely. This can also cause exaggerated responses to sensory inputs, like touch or sound. For example, in a mouse model of autism, the response to whisker movement is weaker in certain brain cells.

Sensory Overload

Autistics often experience sensory overload because their brains can't tune out irrelevant information. This may be due to a failure of brain cells to adapt to continuous stimulation (2).

Visual Processing

PV+ neurons are important for fine-tuning the way we see things, helping us to distinguish between different visual inputs.

Brain Waves and Communication

Increased gamma wave activity, which is linked to sensory and communication issues, is common in autism. PV+ cells help generate these waves, and their dysfunction leads to irregular brain activity patterns (3).

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PlainSpeak for the Lay Reader

A short definition

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References

• 1.Contractor, A., Klyachko, V. A., & Portera-Cailliau, C. (2021). Reduced density and activity of parvalbumin interneurons in autism. Journal of Neurodevelopmental Disorders, 13(1), 1-15.
• 2.Green, S. A., & Gu, Y. (2015). Sensory hypersensitivity in autism spectrum disorders. Current Biology, 25(18), R876-R879.
• 3.Guyon, N., & Nahmani, M. (2021). Role of parvalbumin interneurons in gamma oscillations and sensory processing in autism. Frontiers in Neuroscience, 15, 692872.
• 4. Hussman, J. P. (2001). Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism. Journal of Autism and Developmental Disorders, 31(2), 247-248.
• 5. Rubenstein, J. L., & Merzenich, M. M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes, Brain and Behavior, 2(5), 255-267.

Understanding the E - I Imbalance Theory of Autism

In PlainSpeak for the Lay Reader

Caveat: Always keep in mind there is no single theory that perfectly explains autism.

The Excitatory-Inhibition (E-I) Imbalance idea says that a mix-up between signals that excite and calm the brain can cause the sensory, thinking, and behavior issues in autism.

What Can Cause the E-I Imbalance?

Too Much Glutamate and Overactive Exciting Neurons
Glutamate is the main chemical that makes brain cells more active. If there is too much glutamate or the exciting neurons are too active, it can make the brain overly excitable. This can cause people with autism to be very sensitive to sounds, lights, and other sensory inputs and make thinking and processing information harder.

Not Enough GABA to Calm the Brain
GABA is the main chemical that calms brain cells. In autism, there can be less GABA, problems with GABA receptors, or less active calming neurons. This means the brain doesn’t have enough calming signals to balance the exciting ones, making the E-I imbalance worse.

Problems with Exciting and Calming Neurons
Neurons are the cells in the brain that send and receive signals. Exciting neurons make other neurons more active, while calming neurons reduce activity. In autism, there might be differences in the number, function, or connections of these neurons. For example, changes in certain calming neurons can disrupt the brain’s local circuits, leading to more excitement and less calming.

Important Development Periods
The E-I balance is especially important during key development times when the brain is growing and changing rapidly. If the balance is off during these times, it can affect brain development and function in the long term. This can impact learning, memory, and the formation of proper brain connections.

Changes in Synaptic Proteins

Proteins like neuroligins and neurexins help brain cells stick together and send signals. In autism, changes or problems with these proteins can lead to abnormal connections between brain cells, affecting the E-I balance.

Ion Channel Problems
Ion channels help neurons send signals by letting ions in and out. Ions are tiny charged particles, like sodium, potassium, or calcium, that neurons need to function properly. In autism, problems with these ion channels can change how neurons send signals, affecting the E-I balance.

Problems with Synaptic Plasticity
Synaptic plasticity is the ability of connections between brain cells to get stronger or weaker over time. This is important for learning and memory. Long-term potentiation (LTP) is when these connections get stronger with activity, helping with learning new things. Long-term depression (LTD) is when these connections get weaker, which helps remove unnecessary information. In autism, problems with LTP and LTD can make it harder to learn and remember things.

Role of Supporting Brain Cells (Astrocytes and Microglia)
Astrocytes and microglia are supporting cells in the brain that help maintain E-I balance. Astrocytes manage levels of glutamate and GABA, while microglia help prune synapses during development. Pruning is like trimming a tree; it removes extra connections between brain cells to make the network more efficient. Problems with these cells can lead to too much excitation or not enough inhibition.

Genetic and Epigenetic Factors
Our genes, which are like instructions for how our body works, can influence the E-I balance. Changes in how these genes are turned on or off can also affect the brain. Many genes linked to autism affect how brain cells connect and communicate, leading to differences seen in autism.

Environmental Influences
Things in the environment, like exposure to toxins, infections, and stress during pregnancy, can impact the E-I balance. These factors can change how the brain develops and works, leading to long-term effects on brain signals.

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Predictive Coding Theory of Autism

Predictive coding is a theoretical framework in which the brain is modeled as a hierarchical system that generates predictions about incoming sensory data, constantly updating its internal models to minimize prediction errors. Autism, in the context of predictive coding, is hypothesized to involve atypicalities in how the brain generates, updates, and weights predictions and prediction errors, contributing to sensory sensitivities, repetitive behaviors, and social difficulties.[Read in more detail]

PlainSpeak: Predictive coding is the idea that the brain works like a prediction machine, guessing what’s going to happen next and adjusting when something unexpected happens. Autism might involve the brain having a harder time making and adjusting predictions, which can lead to challenges with senses, routines, and social interactions. [ Read in detail. PlainSpeak Version]

Read in More Detail about Predictive Coding Theory of Autism

For the Scientific/Academic Audience

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A Short Definition

Weak Central Coherence Theory

 PlainSpeak for the Lay Reader

Caveat: There is no single theory that can fully explain autism. 

Weak Central Coherence Theory 

Definition: The Weak Central Coherence Theory suggests that autistics tend to focus more on details rather than the overall picture. This affects how they see and understand the world around them.

The Weak Central Coherence Theory tries to  explain why autistics often excel at noticing details but might struggle with seeing the bigger picture. This unique way of thinking brings both strengths and challenges, affecting everyday tasks, social interactions, and work or hobbies.

Key Concepts

1. Detail-Focused Thinking:

   • What It Means: Autistics are often really good at noticing small details that others might miss.
   • Why It Happens: Their brains are wired in a way that makes them pay extra attention to these details.

2. Difficulty Seeing the Big Picture:

   • What It Means: It can be harder for  autistics to combine these details into a complete, overall understanding of a situation.
   • Why It Happens: The connections in their brains might not work as smoothly to bring all the details together into one big picture.

Examples and Implications

1. Everyday Tasks:

   • Strengths: They might be great at tasks that need attention to detail, like solving puzzles or spotting differences in pictures.
   • Challenges: They might find it harder to understand tasks that need seeing the whole picture, like following a story with lots of characters and events.

2. Social Situations:

   • Challenges: In social settings, understanding body language or implied meanings in conversations can be tough because these require seeing the whole context, not just individual parts.

3. Work and Hobbies:

   • Strengths: Jobs or hobbies that require careful attention to detail, like coding or building models, can be areas where they excel.
   • Challenges: Roles that need quick understanding of complex, big-picture concepts might be more difficult.

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MTT Mental Time Travel

Mental Time Travel (MTT) refers to the cognitive ability to mentally project oneself backward in time to recall past events or forward in time to anticipate future scenarios. In relation to autism, MTT research explores how individuals with autism may experience differences in episodic memory and future-oriented thinking, potentially leading to challenges in recalling specific personal events or imagining detailed future scenarios. [ Read in more detail on MTT]

PlainSpeak: Mental Time Travel (MTT) is our brain’s way of thinking back to past memories or imagining what might happen in the future. For people with autism, MTT might work differently, sometimes making it harder to remember personal events or imagine future plans. [Read in more detail, a PlainSpeak Version]

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Related Posts: [Autism Theories], [Sensorimotor], [Neuroscience of Autism]

Decoding the Excitatory-Inhibition Imbalance in Autism

Caveat: Always keep in mind there is no single theory that perfectly explains autism.


The Excitatory-Inhibition (E-I) Imbalance hypothesis posits that an imbalance between excitatory and inhibitory signaling in the brain contributes to the sensory, cognitive, and behavioral features of autism.

Factors that contribute to the E-I imbalance.

Elevated Glutamate and Hyperactive Glutamatergic Neurons

Glutamate is the primary excitatory neurotransmitter in the brain, and its excessive release or receptor overactivation can lead to heightened neuronal excitability. Research indicates that autistics have increased glutamate concentrations in certain brain regions, suggesting a hyper-excitable state that disrupts normal neural communication and network dynamics. This over-excitation can manifest in the form of heightened sensitivity to sensory stimuli and difficulties in cognitive processing.


GABAergic Signaling Deficit

GABA is the primary inhibitory neurotransmitter, crucial for counterbalancing excitation. In autism, there is often a reduction in GABAergic signaling, whether through decreased GABA levels, impaired GABA receptor function, or reduced GABAergic neuron activity. This means that the inhibitory 'brake' on neuronal activity is weakened, failing to counteract the excessive excitation from glutamate, thus exacerbating the E-I imbalance.

Imbalance in Pyramidal Neurons and Interneurons

Pyramidal neurons are the primary excitatory cells in the cortex, while interneurons provide the necessary inhibitory control. In autism, there are differences in the density, function, and connectivity of these neuron types eg: alterations in the number or function of specific types of inhibitory interneurons, such as parvalbumin-positive (PV+) interneurons. These changes disrupt the local circuitry, leading to an overall increase in excitation and reduced inhibition.

Critical Developmental Periods

E-I imbalance is particularly impactful during critical developmental periods when the brain is highly plastic and sensitive to changes. Early disruptions in E-I balance can have long-lasting effects on brain development and function. During these periods, the maturation of both excitatory and inhibitory circuits is crucial for establishing proper neural networks. If the E-I balance is skewed, it can impair synaptic plasticity, cortical maturation, and the formation of functional neural circuits, contributing to the developmental trajectory of autism.

Alterations in Synaptic Proteins

Changes in the expression or function of synaptic proteins play a critical role in E-I imbalance. Proteins such as neuroligins and neurexins, which are involved in synaptic adhesion and signaling, have been implicated in autism. Mutations or dysregulation of these proteins can lead to atypical synapse formation and function, contributing to an imbalance between excitatory and inhibitory synapses.

Ion Channel Dysfunction

Ion channels are essential for maintaining the proper function of neurons. Dysfunctions in ion channels, such as those involving sodium, potassium, and calcium, can alter neuronal excitability. In autism, mutations in genes encoding these ion channels (e.g., SCN2A, KCNQ2) have been identified, leading to altered action potential generation and propagation, thereby affecting the E-I balance.

Impaired Synaptic Plasticity

Synaptic plasticity, the ability of synapses to strengthen or weaken over time, is crucial for learning and memory. Long-term potentiation (LTP) and long-term depression (LTD) are key mechanisms of synaptic plasticity that depend on a delicate E-I balance. In autism, impairments in LTP and LTD have been observed, suggesting that the capacity for synaptic change is disrupted, further contributing to cognitive and behavioral challenges.

Role of Astrocytes and Microglia

Astrocytes and microglia, types of glial cells, also play significant roles in maintaining E-I balance. Astrocytes regulate neurotransmitter levels, including glutamate and GABA, by uptake and recycling processes. Dysregulation of astrocyte function can lead to excess glutamate and insufficient GABA, exacerbating E-I imbalance. Microglia, the brain's immune cells, are involved in synaptic pruning during development. Abnormal microglial activity can lead to either excessive or insufficient synaptic pruning, disrupting the E-I balance and normal brain connectivity.

Genetic and Epigenetic Factors

Genetic mutations and epigenetic modifications can influence E-I balance. Numerous genes associated with autism are involved in synaptic function, neurotransmitter systems, and neuronal development. Additionally, epigenetic changes, such as DNA methylation and histone modification, can alter gene expression patterns related to E-I balance. These genetic and epigenetic factors contribute to the heterogeneity observed in autism, affecting the degree and nature of E-I imbalance across individuals.

Environmental Influences

Environmental factors, including prenatal exposure to toxins, infections, and stress, can impact E-I balance. These factors can alter the development of neural circuits and neurotransmitter systems, leading to long-term changes in excitatory and inhibitory signaling. Understanding the interaction between genetic predisposition and environmental influences is crucial for comprehending the full picture of E-I imbalance in autism.

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Weak Central Coherence Theory of Autism

Autism Lexicon: Weak Central Coherence (WCC) Theory

The WCC Theory is a cognitive theory of autism (cognitive theories try to explain how autistics think). 

It suggests that  autistics focus on noticing details but might struggle with seeing the bigger picture. This affects how they see and understand the world around them. This unique way of thinking brings both strengths and challenges, affecting everyday tasks, social interactions, and work or hobbies.

Read about WCC in more detail 

For the Academic/Scientific Audience

PlainSpeak Plain Language for the Lay Reader

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Other posts on WCC

Other Theories of Autism

Cognitive Theories and Sensorimotor Explanations for Autism

While no single theory or idea fully explains all aspects of autism, each attempts to provide insights into different cognitive, sensory or behavioral characteristics associated with autism or the history behind why things could be the way they are. Here are some of the theories, ideas and issues. they can also be found in posts in the following hashtags [#sensorimotor] [#AutismTheories]

• Active Sensing
• Alexithymia
• Apraxia
• Asset Framing
• Attribution Errors
• Autistic Burnout
• Autistic Inertia
• Blindsight
• Body Schema
• Camoflauging
• Catatonia
• Cocktail Party Effect
• Cognitive Dissonance Theory
• Depersonalization
• Double Empathy Problem
• Dyspraxia
• ECCT - Executive and Contextual Control Theory 
• E-I Imbalance Theory
• EPF - Enhanced Perceptual Functioning Model
• ES Theory of Autism
• Executive Dysfunction Theory
• Exteroception
• Flat Effect
• Fluid & Crystallized Intelligence
• Hostile Attribution Bias
• Implicit and Explicit Bias
• Intense World Theory
• Interoception
• Linear & Non Linear Thinking
• Local and Distributed Information
• Lucid Dreaming
• Masking
• Mental Age 
• Mental Time Travel
• Monotropism
• Multiple Intelligences 
• Neuronal Pruning Theory
• Negative Attribution Bias
• Neuroception
• Peripersonal Space (My area of research)
• Predictive Coding Theories
• Predictive Homeostatis Theory
• Propagnosia
• PV Neuron Hypothesis
• Sensory Processing (see #Sensorimotor)
• Social Motivation Theory
• Special Interests (SPIN)
• Spoon Theory
• Stimming
• Synesthesia
• Temporal Binding Window
• Theory of Mind
• Triple Bind and Masking 
• Weak Central Coherence Theory

PV hypothesis of autism

 Background and Rationale

The Parvalbumin (PV) hypothesis of autism proposes that dysfunction in PV-expressing interneurons (INs) underlies many of the core features of autism. Despite the heterogeneity in genetic and environmental factors contributing to autism, there is a remarkable similarity in the atypical behaviors observed, suggesting a common pathophysiology across brain regions (Contractor et al., 2021).

The Parvalbumin hypothesis of autism underscores the critical role of PV+ interneurons in maintaining neural circuit balance. Their dysfunction leads to various neurological and behavioral abnormalities observed in autism, such as sensory hypersensitivity and seizures.

Evolution of the E/I Imbalance Theory

Initially, the theory of excitation/inhibition (E/I) imbalance was proposed, suggesting that reduced GABAergic inhibition leads to an increased E/I ratio, which correlates with delayed cortical maturation in autism (Hussman, 2001; Rubenstein & Merzenich, 2003). This model explains the co-occurrence of seizures in autism but has limitations due to the involvement of various cell types in regulating E/I balance, making it difficult to identify specific therapeutic targets. A more nuanced approach involves examining different IN subtypes under behaviorally relevant brain states.

Evidence for PV+ Cell Hypofunction in Autism

Recent findings highlight several key aspects of PV+ cell hypofunction in autism:

• Reduced density of PV INs: Lower expression of PV protein and decreased density of perineuronal nets (PNNs) around INs.
• Increased power of baseline gamma oscillations: Gamma oscillations, regulated by PV and somatostatin (SST) INs, show increased power in autism.
• Decreased activity of PV INs: Reduced visually-evoked activity in PV INs.

PV INs are the most prevalent IN subtype in the cortex, but this does not exclude the possibility that other IN subtypes are involved.

Hyperexcitability and Hypersynchrony

PV hypofunction leads to hyperexcitability and hypersynchrony, predisposing individuals to seizures and exaggerated sensory-evoked responses in pyramidal (Pyr) neurons of sensory cortices. For instance, whisker-evoked responses are suppressed in Layer 2/3 neurons of the primary somatosensory cortex (S1) in Fmr1 knockout (KO) mice, a model of autism.

Sensory Hypersensitivity

A failure of neurons to adapt to ongoing stimulation, observed in Fmr1 KO mice and autistic humans, may contribute to sensory hypersensitivity. This lack of neuronal adaptation can prevent individuals from tuning out irrelevant stimuli (Green et al., 2015).

Role of PV+ Neurons in Visual Processing

PV+ neurons are crucial for modulating the tuning of Pyr neurons in the primary visual cortex (V1), thereby improving visual discrimination.

Gamma Oscillations and Other Brain Rhythms

Increased power of resting-state gamma band oscillatory activity (> 30 Hz) is associated with sensory processing and communication deficits in autism and fragile X syndrome (FXS). PV INs are critical in generating gamma rhythms. PV hypofunction, as seen after PV cell-specific deletion of the NR1 subunit of NMDA-type glutamate receptors, results in increased broadband gamma power due to decreased synchronicity (Guyon et al., 2021).

2 Versions of this Post

For the Science/Academic Reader

PlainSpeak for the Lay Reader

A short definition

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References

• Contractor, A., Klyachko, V. A., & Portera-Cailliau, C. (2021). Reduced density and activity of parvalbumin interneurons in autism. Journal of Neurodevelopmental Disorders, 13(1), 1-15.
• Green, S. A., & Gu, Y. (2015). Sensory hypersensitivity in autism spectrum disorders. Current Biology, 25(18), R876-R879.
• Guyon, N., & Nahmani, M. (2021). Role of parvalbumin interneurons in gamma oscillations and sensory processing in autism. Frontiers in Neuroscience, 15, 692872.
• Hussman, J. P. (2001). Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism. Journal of Autism and Developmental Disorders, 31(2), 247-248.
• Rubenstein, J. L., & Merzenich, M. M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes, Brain and Behavior, 2(5), 255-267.

Understanding Predictive Coding in the Brain

In PlainSpeak for the Lay Reader 

Researchers have come up with many theories to try to explain different aspects of thinking and behavior in autism. The Predictive Coding Hypothesis is one such set of explanations. 

Understanding Predictive Coding in the Brain 

This hypothesis says that the brain acts like a prediction machine, always guessing what's going to happen based on past experiences. For example, if you hear a familiar sound, like a door creaking, your brain might predict that someone is entering the room. When something happens, the brain compares it to what it expected and updates its guesses to be more accurate next time.

Predictive Coding in Autism

Scientists think that the brains of autistic people might process these predictions differently. This could explain some common characteristics of autism, like sensory sensitivities, repetitive behaviors, and social challenges.

Slow Updating Theories

What This Means: Autistic people might update their brain’s predictions more slowly. This means their brain doesn’t adjust as quickly when something new or unexpected happens.

Possible Effects:

• Repetitive Behaviors: They might rely more on routines or repetitive actions to cope with the world because it feels more predictable and safe.
• Sensory Sensitivities: Because their brain takes longer to adjust, unexpected noises, lights, or touches might feel very intense or overwhelming.
• Social Challenges: Social interactions often require quick thinking and adapting, so slow updating might make it harder to understand and react to what others are doing or saying.

Examples of Slow Updating Theories:

1. Predictive Coding Deficit Theory: Autistic people may have a harder time updating their brain’s predictions with new information, which can make adjusting to changes difficult.
2. Reduced Sensory Prediction Error Theory: The brain might not be good at noticing when it made a wrong prediction, leading to slower updates and more intense sensory experiences.

High-Precision Theories

What This Means: Autistic people might focus too much on the details of what they sense, giving a lot of importance to every little thing they see, hear, or feel.

Possible Effects:

• Sensory Overload: Because they notice so many details, it can become overwhelming and lead to sensory overload.
• Literal Thinking: They might take things very literally and have trouble understanding implied meanings or jokes.
• Detail-Oriented: They might focus a lot on small details but find it hard to see the bigger picture.

Examples of High-Precision Theories:

1. Aberrant Precision of Prediction Errors: Autistic people might give too much importance to their senses, leading to strong reactions to things like noise or bright lights.
2. Increased Sensory Precision Theory: Their brain treats all sensory input as very important, making it hard to ignore unimportant details.
3. Attenuated Priors Hypothesis: Their brain’s expectations (or “priors”) are weaker, so they rely more on the immediate sensory input, giving it more weight.

Other Theories in Autism

Aberrant Salience Theory: Autistic people might over- or under-estimate the importance of certain things they sense, which can make it hard to focus on what really matters.

Precision of Priors and Prediction Errors: There might be an imbalance in how the brain handles predictions and errors. This could lead to rigid behaviors or heightened sensory responses.

Adaptive Coding Hypothesis: The brain of an autistic person might be tuned differently, focusing on details that others might not notice. This could explain both their strengths, like noticing small details, and challenges, like understanding social cues.

Enhanced Perceptual Functioning Model: Autistic people might be really good at noticing small details but might struggle to see the bigger picture.

Predictive Homeostasis Theory: Autistic people might aim to keep their brain in a balanced state, which could explain why they prefer routines and predictability.

Intense World Theory: The brain of an autistic person might be hyper-sensitive, making the world feel very intense. This might lead to sensory overload and a preference for predictable environments.

Combining Theories

These different theories aren’t mutually exclusive; they can coexist in the same person. For example, someone might experience both slow updating and high precision, leading to a mix of challenges, like sensory overload and a need for routines.

Autism and Abstract Thinking

There’s a stereotype that autistic people can’t think abstractly or see the big picture. This isn’t true for everyone. While some autistic individuals might focus on details, many also excel in areas that require abstract thinking, like art, poetry, and storytelling. These creative activities often involve both concrete details and abstract ideas, showing the diverse cognitive strengths within the autistic community.

Final Thoughts

Understanding how autistic people think and process information is complex, and these theories help provide some explanations. However, it’s important to remember that every autistic person is different, and more research is needed to better understand and support them. There’s no one-size-fits-all approach to autism, and each person’s unique experience should be respected.

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For the Scientific/Academic Audience

PlainSpeak Plain Language for Lay Reader

A Short Definition

Understanding Mental Time Travel and Autism

A PlainSpeak Plain Language version for Lay Reader

What is Mental Time Travel (MTT)?

MTT is our brain's amazing ability to think back to past events or imagine what might happen in the future. For example, you might think back to a fun birthday party or imagine what your next vacation will be like. MTT helps us move through time in our minds, so we can remember, plan, and dream.

How Do Scientists Measure MTT?
Scientists have a way to measure this ability called the MTT Task. In this task, people are given words like "graduation" or "vacation" and asked to either remember something from their own life or imagine something in the future. For example, you might think of your own graduation day in the past or imagine what a future vacation could be like.

Scientists use this task to understand how well people can remember specific events from their lives (like their own birthday) or think about events that could happen in the future (like planning a holiday). This helps them learn more about how our brains work when we think about the past and future, especially in people with different conditions like aging or mental health issues.

MTT and Autism: What Do We Know?

Scientists are starting to learn that autistics might think about the past and future a little differently. Some autistics might find it hard to remember specific personal events or to imagine detailed future plans. This could be because of differences in how their brains work when recalling memories or imagining the future.

But it's important to remember that everyone with autism is different. Some may find these tasks easy, while others may find them more challenging. By studying how autistics use MTT, scientists hope to learn more about how they think about time and how we can better support them.

Future research could look at

• How Autistics Remember: Understanding how autistics remember personal events and how this might be different from others.
• Imagination and Planning: Learning more about how autistics imagine the future and plan for it.
• Brain Studies: Using special brain scans to see how the parts of the brain involved in MTT might work differently in autistics.

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Versions of this post: [MTT PlainSpeak For the Lay Reader], [MTT For the Academic/Science Reader], [A Simple Definition of MTT]

Related Posts: [Autism Theories], [Sensorimotor], [Neuroscience of Autism]

Oddball Paradigms in Autism Research

Lexicon: Oddball Paradigms

Oddball trials, also known as oddball tasks or oddball paradigms, are a type of research experimental design used in cognitive and sensorimotor research. The oddball paradigm has been widely used in autism research to investigate sensory processing differences, attentional issues, and cognitive control. During an oddball task, researchers typically measure various physiological and behavioral responses, such as reaction times, accuracy rates, ERPs (via EEG) or fMRI (to examine neural activity patterns).

The oddball paradigm typically consists of two types of stimuli and participants are asked to detect and respond to the oddball.

• Standard Stimuli: These are the most common stimuli presented in the sequence and serve as the baseline / control stimuli, occurring with higher frequency. Participants are generally instructed to ignore standard stimuli and withhold any response to them
• Target Stimuli: These are the less frequent or "oddball" stimuli that differ in some way from the standard stimuli. The target stimuli can be defined by various characteristics, such as a different color, shape, sound, or any other perceptual feature.

The purpose of oddball trials is to investigate how the brain processes and detects rare or deviant stimuli amidst a background of more common stimuli. By manipulating the frequency and characteristics of the target and standard stimuli, researchers can examine various aspects of cognitive processing, including

• Attention: how participants allocate and sustain their attention to detect infrequent target stimuli. It allows researchers to explore the mechanisms of selective attention, attentional capture, and the ability to filter out irrelevant information.
• Perception & perceptual processing: how the brain discriminates between different stimuli; how the brain detects and discriminates deviant stimuli based on sensory features, and how it forms representations and expectations about the environment
• Memory and Cognitive Control: Participants may be required to remember the occurrence or characteristics of the target stimuli and maintain this information for subsequent recall or recognition. Also sheds light on cognitive control processes, such as response inhibition and response selection when distinguishing between standard and target stimuli.

Oddball Paradigms in Autism Research

Oddball paradigms in autism research, offer a window into the sensory processing differences, attentional mechanisms, and cognitive control capabilities.

1. Sensory Processing Differences: One of the core areas of investigation in autism is sensory processing as autistics often exhibit atypical responses to sensory stimuli, which can range from heightened sensitivity to specific stimuli to a diminished response to others. Oddball paradigms help researchers understand these sensory anomalies by comparing how autistics detect and respond to infrequent target stimuli compared to neurotypical controls. This can reveal whether there is an enhanced perceptual sensitivity or other unique patterns of sensory processing in autism.

2. Attention and Attentional Allocation: Studies focus on how autistics sustain and allocate their attention when faced with rare target stimuli amidst a stream of more common stimuli. Findings often indicate differences in how attention is captured and maintained, which can be linked to broader attentional issues in autism. For instance, some research suggests autistics may focus more on local details rather than global features of stimuli (Weak Central Coherence theory)

3. Cognitive Control and Inhibition: Cognitive control, including response inhibition and flexibility in shifting attention, is frequently assessed through oddball tasks. These tasks can highlight the executive functioning issues, such as challenges with inhibiting inappropriate responses or switching attention between different tasks or stimuli.

Key Findings from Autism Research

Research using oddball paradigms has provided several key insights into the neurocognitive characteristics of ASD:

• Enhanced Perceptual Sensitivity: Some studies suggest that autistics may exhibit enhanced perceptual sensitivity, reacting more quickly or accurately to target stimuli than neurotypical individuals. This heightened sensitivity might be associated with an increased focus on specific features in the environment.

• Atypical Neural Responses:  Differences in the amplitude and latency of ERP components, such as the P3 wave, which is linked to attentional processes and cognitive evaluation, have been noted (1).

• Attentional Allocation Differences: The way individuals with autism allocate their attention during oddball tasks often differs from that of neurotypical individuals. This can include a tendency to focus more narrowly on specific stimuli aspects, potentially reflecting a unique attentional strategy or sensory processing style (2).

• Cognitive Control Challenges: Oddball tasks also reveal cognitive control issues, such as difficulties with response inhibition and flexibility in attention shifting. These findings are consistent with broader patterns of executive dysfunction observed in autism (3).

2 versions of this post

PlainSpeak. In plain language for the Lay Reader

For the scientific/academic reader

References:

1. Gomot, M., et al. (2008). Atypical auditory processing in children with autism: A cohort study with event-related potentials. Journal of Autism and Developmental Disorders, 38(7), 1307-1316.
2. Sokhadze, E. M., et al. (2009). Atypical prefrontal cortex development in autism: ERP evidence of abnormal inhibitory control in a Go/NoGo task. Behavioral and Brain Functions, 5, 9.
3. Hill, E. L. (2004). Executive dysfunction in autism: A review of the evidence for specific deficits. Developmental Psychopathology, 16(3), 377-401.

Perception Runs Independently

 Perception Runs Independently

The Strengths and Challenges of Autonomous Sensory Processing

One of the most fascinating aspects of the Enhanced Perceptual Functioning (EPF) model is the idea that, for many autistic individuals, sensory processing operates more independently from higher-level cognitive influences, like attention or expectation. This can be understood through the concepts of top-down and bottom-up processing—two different ways the brain handles sensory information.

 
Top-Down vs. Bottom-Up Processing:

In a neurotypical brain, sensory processing often follows a top-down model, where the brain relies on past experiences, expectations, and context to interpret incoming sensory information. Top-down processing is heavily influenced by cognitive control areas, such as the prefrontal cortex (PFC), which helps direct attention and filter out irrelevant stimuli. This kind of processing ensures that we don’t get overwhelmed by the sheer volume of sensory data—our brains focus on what we expect to see or hear, filling in the gaps based on previous experiences.

For example, when you walk through a busy street, your frontal cortex might direct your attention to familiar sounds, like a car engine or a friend's voice, while tuning out irrelevant details like background noise. This ability to prioritize sensory input helps you function efficiently, without being overwhelmed by the countless stimuli around you.

In contrast, the EPF model suggests that autistics experience a stronger reliance on bottom-up sensory processing. This means that their brains process raw sensory input before cognitive filters have a chance to influence what is perceived. Bottom-up processing starts in the sensory pathways—for instance, visual information is processed from the eyes through the thalamus to the primary visual cortex in the occipital lobe, and auditory information moves from the ears through the thalamus to the primary auditory cortex in the temporal lobe.

In this bottom-up process, the brain takes in a more direct and unfiltered version of sensory input, without as much modulation from higher cognitive regions like the prefrontal cortex. As a result, the autistic brain may prioritize details that neurotypical brains might quickly dismiss. While this means autistic individuals often have a clearer, more detailed perception, it also means their brains may struggle to filter out irrelevant stimuli in a noisy environment, leading to sensory overload.

The Role of Attention and Sensory Pathways
The differences in top-down and bottom-up processing in autism can also be understood in terms of how the brain handles attention. In neurotypical individuals, the dorsal attention network (DAN) and ventral attention network (VAN) play key roles in guiding attention to relevant stimuli. The DAN, which involves regions like the intraparietal sulcus (IPS) and the frontal eye fields, helps direct voluntary attention to important stimuli based on goals or expectations (top-down). The VAN, which includes areas like the temporo-parietal junction (TPJ), responds to unexpected but relevant sensory information (bottom-up).

In autistics, research suggests that these attentional networks may function differently. The brain might have a harder time using top-down signals from areas like the prefrontal cortex to guide attention, leading to an increased reliance on bottom-up sensory input. This could explain why many autistic people seem to notice small details others miss—their brains are less influenced by pre-existing expectations and more tuned in to the raw sensory data arriving from their environment.

This also ties into findings of hyperconnectivity or altered connectivity between sensory regions and higher cognitive areas in autism. Studies using fMRI (functional magnetic resonance imaging) have shown that autistic brains may have more local connectivity in sensory areas, meaning that signals in these regions are processed more intensely, while long-range connectivity to cognitive control areas may be weaker. This imbalance can contribute to heightened sensory experiences and challenges with regulating attention.

A Clearer, Less Biased Perception

The benefit of this autonomy is that autistic individuals often perceive the world in a way that is less biased by assumptions or distractions. For example, while a NT brain might overlook subtle differences in a visual scene because it’s focused on the overall picture or expected patterns, an autistic may notice these fine details with ease. This ability to see things without the brain’s automatic filters allows for incredibly precise perception in many situations.

Consider the case of an autistic artist. While many people would glance at a tree and interpret its general shape and structure, an autistic artist might perceive the unique texture of the bark, the subtle variations in leaf color, or the intricate patterns of shadow and light. These details aren’t blurred by the brain’s expectations of what a tree "should" look like—they are seen as they truly are.

This enhanced attention to detail has clear advantages in fields that rely on precision. This may explain why some autistics may excel in areas like programming, scientific research, music, and visual arts because their brain processes sensory information in a highly accurate, detailed way that isn’t as easily influenced by preconceived ideas.

Sensory Pathways and Overload

The way sensory information travels in the brain also provides insight into why sensory overload can be more common in autistic individuals. In a neurotypical brain, the thalamus, often referred to as the brain’s “sensory relay station,” plays a major role in filtering out unnecessary sensory input before it reaches the cortex. However, research has suggested that in autism, the thalamus may not perform this filtering function as effectively, allowing more sensory data to pass through to higher brain regions.

Once this unfiltered sensory information reaches the cortex, the autistic brain—especially with heightened local connectivity in sensory areas—may amplify the sensory experience. This is why an autistic individual walking through a crowded mall might be overwhelmed by every sound, every light, every movement around them. Their brain is processing all stimuli equally, without prioritizing which are most important for the situation.

However, this independence from top-down cognitive filtering comes with its own set of challenges, particularly when it comes to sensory overload. Imagine walking through a crowded mall. For most people, the brain quickly decides what sensory information is relevant—focusing on navigating the crowd and maybe listening to the person they’re walking with, while tuning out background music, chatter, and bright displays.

In contrast, an autistic individual may perceive all the stimuli equally, because their brain isn’t filtering out irrelevant details as efficiently. The result can be overwhelming. Every sound, every light, every movement is processed with equal importance, which can make it incredibly difficult to focus on any one task. This is why autistic individuals often report feeling overwhelmed or anxious in environments that are filled with sensory input—there’s simply too much to take in.

This phenomenon is a key part of what many call sensory hypersensitivity in autism. The inability to tune out irrelevant stimuli doesn’t mean that the brain is malfunctioning; rather, it’s processing far more information than the average person. While this can lead to sensory overload, it also means that in more controlled environments, autistic individuals can exhibit an extraordinary level of focus on tasks that rely on the ability to notice and analyze small details.

Balancing Strengths and Challenges

The EPF model presents both strengths and challenges due to this reliance on bottom-up processing. On the positive side, it explains why many autistic individuals excel in areas requiring high attention to detail. The precision of their perception allows them to see, hear, and feel things that others might miss, making them particularly skilled in fields like art, music, programming, and scientific research.

However, the same ability that allows for such detailed perception can also lead to sensory overload in environments with a lot of stimuli. Without the same level of filtering, every sound, every sight, and every touch is processed with equal importance, which can make it hard to focus on any one thing.

Supporting Autistic Sensory Processing


The EPF model encourages us to view this type of sensory processing not as a defect but as a different way of experiencing the world. The challenge, then, is to find ways to support autistic individuals in environments that might overwhelm their senses, while also allowing them to harness their heightened perceptual abilities in ways that suit them.

Understanding how top-down and bottom-up processing work differently in autism helps us find better ways to support autistic individuals. For example, in educational settings, creating sensory-friendly environments—with softer lighting, quieter spaces, and less clutter—can help reduce the burden of sensory overload. Allowing students to use noise-canceling headphones or providing breaks in quieter areas can help them manage sensory input more effectively.

In the workplace, offering flexible environments or hybrid work options where autistic employees can adjust lighting or reduce noise can allow them to focus on their strengths, like attention to detail. By recognizing the autonomy of their sensory processing, we can create spaces that support both their sensory needs and their abilities.

Predictive Homeostasis Theory

 

While no single theory fully explains all aspects of autism, each attempts to provide insights into different cognitive and behavioral characteristics.

Predictive Homeostasis Theory

• This theory proposes that the predictive coding system in autism might be tuned to maintain a state of homeostasis, leading to atypical responses to changes and novelty.
• Implications: A preference for routine and predictability, challenges in adapting to new or unexpected situations, and a tendency to engage in repetitive behaviors to maintain predictability.

Read more on [Predictive Homeostatis Theory][Predictive Coding Theory]

Posts on other [Theories of Autism]