The Parvalbumin (PV) hypothesis of autism suggests that dysfunction in PV-expressing interneurons leads to an imbalance in excitation and inhibition, contributing to core features of autism such as sensory hypersensitivity and seizures. [Read in more detail For the Science/Academic Reader]
Layspeak: The PV hypothesis of autism proposes that problems with specific brain cells called PV neurons cause an imbalance in brain signals, leading to common autism traits like sensitivity to sensory inputs and a higher chance of seizures. [Read in more Detail PlainSpeak for the Lay Reader]
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